Middlesbrough registered their first away win of the season on Saturday and are fancied to follow it up with victory at Preston on Tuesday night.
Tony Mowbray was delighted with what he described as several "immense performances" at Ewood Park, particular that of striker Lukas Jutkiewicz who justified his selection with a brace.
"Every day in training we've had to calm him down a bit, he's been bursting out of his shirt to show us he wants to start," Mowbray told BBC Tees when asked about his starring striker.
"He was a real handful tonight and gives us a platform to play off.
"If you've got people like [Marvin] Emnes, [Mustapha] Carayol and [Josh] McEachran who are really clever, creative footballers sometimes they need the ball up that end of the pitch to be able to play.
"If you can play off Jutky and get people running at people off him in the final third then you've got a real problem [for the opposition]."
Equally as encouraging for the manager was the performance of Jonathan Woodgate, who started for the third time in the space of a week, and with six wins from nine games in all competitions this season there's a real buzz around Boro.
That could spell danger for Preston, who have knocked out Crystal Palace and Huddersfield to reach the last 16 but will surely find this tougher.
Graham Westley's side were beaten 3-1 at Walsall at the weekend, and though their early-season home form has a solid look to it they were, by all accounts, flattered to lose 2-1 to Crawley at Deepdale earlier this month.
History is also firmly against them, with Preston having been eliminated at this stage of the competition in each of the last three seasons.
2004 champions Middlesbrough, meanwhile, haven't been knocked out by a third-tier outfit since 1984, and have won on three of their last four trips to Preston. Indeed, this pair have met five times in the last decade and Boro are unbeaten, winning three.
Mowbray may rest a few of his squad but Marvin Emnes has started both League Cup games so far and the threat of him and the promising Cameron Park is one that Preston will find difficult to deal with.
Both of the aforementioned games were away from home against lower-league opposition, and at 17/10 Middlesbrough are worth backing to repeat the trick here.
Elsewhere, we'll play a small double on Everton and Southampton both of whom look good value at around the 5/6 mark.
Everton's excellent start to the season has been well-documented and their performance at Swansea on Saturday has them firmly on the front foot ahead of a trip east to Leeds.
Neil Warnock's side bounced back to form by beating Nottingham Forest on Saturday but in doing so they once again demonstrated that visiting sides can expect chances, and Everton should take advantage.
David Moyes started the likes of Phil Neville, Kevin Mirallas, Victor Anichebe. Leon Osman, Leighton Baines and Phil Jagielka in the second round despite the fact his side played host to Leyton Orient, and that determination to go deep into this competition should be rewarded.
Some will look back to 2010's penalty shootout defeat at Brentford as evidence that the Toffees are vulnerable in this competition, but that was simply an off-day from a near-full strength side, and providing Everton turn up in the form they've shown consistently this season they really should make 5/6 quotes appear generous.
Similarly, Southampton can make it back-to-back wins by taking care of Sheffield Wednesday.
Nigel Adkins was delighted with the performance of his players against Aston Villa on Saturday, and that 4-1 win was due reward for some gallant efforts in defeat against three of the best sides in the Premier League.
It was a strong enough Saints side that went to Stevenage and won 4-1 in the second round of this competition, and they have enough depth to rotate and still take care of Wednesday.
Dave Jones has seen his side lose their last four in the Championship, and their solitary away point this season came courtesy of a last minute equaliser at Derby on the opening day.
Wednesday deserve credit for reaching this stage having knocked out Fulham in round two, but their journey should end here.