Hodgson said at the post-match news conference: "We have to accept we weren't quite good enough over the 120 mins.
"Then we went down the same road we have gone down so many times before. A penalty shoot-out isn't a game of football. It is a different competition.
"I have been very happy with what I have seen from this group of players. This tournament has been very useful for the young players."
England goalkeeper Joe Hart admitted he felt "terrible" after being knocked out of the competition
He said on Radio Five Live: "We've gone out of a tournament that we've laid the foundations for really well, played with everything we've got and unfortunately we weren't good enough tonight, losing on penalties."
England rode their luck on occasion during the match with Italy, twice hitting the woodwork as well as creating a number of other decent chances.
The Azzurri also thought they had won the match six minutes from time only to see Antonio Nocerino's header correctly ruled out for offside.
Asked if he thought it was going to be England's night after those escapes, Hart said: "I thought it was going to be our night whether those things didn't happen.
"I thought it was going to be our night because of the side we had, the heart we had, the quality we had, but unfortunately it wasn't to be, we didn't do well in the shoot-out, myself included."
The Manchester City custodian also admitted he was struggling to take many positives from the experience immediately after the match.
"I'd like to be optimistic now but that's not the feeling in my heart at the moment," he said. "I'm an emotional guy and I put everything I had into these past couple of weeks.
"I'm gutted for the people who paid money to come out here to support us and see us and for the people back home."
On how he will reflect back on the tournament overall, Hart added: "Right now, not well. We'll have to wait and see in a couple of days."
Hart may have been struggling for positives but Hodgson was optimistic about the future.
He said: "If this group of players continues to show the same degree of determination and the will to be a team, and to work hard as a team, we've got quality players to come into our squad who will obviously to add to the competition...I'm convinced it won't be that long before we beat a top nation in a competition.
"We had our chance today and we came close to taking it but not quite, but I think we've just got to keep building on what we've done in this tournament.
"We've got to make certain the good things that we've done remain and we've got to keep working on the aspects of our play where we could be a little bit better."
Wayne Rooney admitted "it was a horrible way to go out".
"We are all gutted," said Rooney.
"It was a tough game and we all worked hard, so to lose on penalties is a horrible feeling for everyone."
But he added: "We can hold our heads up high. There are a lot of young players in the squad and that will help them in next tournament."
Winger Theo Walcott could only express his sorrow.
"It's a very cruel way to go out in any competition but someone was going to go out and luck did not go our way," he said.
"The two Ashleys are strong enough lads to come back from this and the lads will be with them.
"They are two of the most experienced players in that dressing room and they will bounce back from this even better players.
"I do not worry about that at all.
"We have got to look forward to the future. It is going to be bright, I am sure of that.
"The World Cup qualifiers are going to be tough. We have to learn some lessons from tonight as that is important for the young players - me being one of them."
Italy midfielder Andrea Pirlo could not disguise his happiness, though, as he looked ahead to Thursday's semi-final with Germany in Warsaw.
"I'm very happy to get the man-of-the-match award, but the most important thing is the side have gone through to the semi-finals," he said.
"We deserved to do so.
"Now we have a semi against Germany to come, and we're all hopeful of getting through right to the end of the tournament."
Cesare Prandelli admits Germany are "favourites" to win the semi-final after praising Italy's "deserved" win.
"We have played a great game," the Italy coach told Rai TV.
"We deserved the win. We were really good against a big team like England. Then, at penalties, what is also needed is luck.
"This evening we played with heart, character and ideas against a difficult side. I also want to underline the spirit we showed.
"Are Germany favourites for the semi-final? Absolutely yes, but now let's celebrate this win and then we will think about the semi-final."